Hot Sale Automatic Flowmeter Fermentation Machine for Pharmaceutical Industry

• Customization: Available
• Application: Pharmaceutical Industry
• Disposable: No
• Model NO.: BEYOND
• Injection Site: Intramuscular
• Material: SUS316L/SUS304
• Needle Gauge: 30G
• Safety Feature: Auto-Retractable Needle
• Usage: Medical
• Warranty: 1 Year
• Name: microorganism bioreactor
• Capacity: 50L-5000L
• Type: Preparation Machinery
• Finished Dosage Form: Liquid
• Precision: High Precision
• Certification: CE, ISO
• Voltage: 380V
• Computerized: Computerized
• Customized: Customized
• Condition: New
• After-sales Service: provided
• Transport Package: Standard Export Packing
• Specification: 50L-5000L
• Trademark: Beyond
• Origin: Shanghai China
• HS Code: 8443200000
• Production Capacity: 100 Pieces/ Month

Product Description

Hot Sale Automatic Flowmeter Fermentation Machine for Pharmaceutical Industry

Vortex Flowmeter is a flow measurement instrument based on the Karman Vortex Principle, widely used for flow detection of gases, liquids, and vapors. It calculates the flow rate by detecting the frequency of vortices generated alternately on both sides downstream of the bluff body (usually a cylindrical object) when the fluid flows through it. This flowmeter does not require a straight pipe section, is easy to install, has a wide measurement range, and high accuracy, especially suitable for measuring flow in large pipelines. As for the fermentation machine, it is an important equipment used in the fields of biotechnology, food industry, and pharmaceuticals for microbial or cell culture to produce specific products such as alcohol, enzymes, antibiotics, etc.

The fermentation process usually requires temperature control PH value, oxygen supply and other conditions are used to optimize the yield of the target product. The fermentation machine can be a simple tank reactor, or a highly automated large-scale bioreactor equipped with precision sensors and control systems. Applying a vortex flowmeter to a fermentation machine to accurately measure the flow rate of materials entering and exiting the fermentation tank, such as air flow (crucial for aerobic fermentation), medium flow, or product output flow. This can help operators better control the fermentation process, ensure the stability of fermentation conditions and product quality.


Nominal volume: 10L,15L ,30L,50L,70L,100L,150L,200L

Liquid loading coefficient: ≥70%

Tank configuration : 

Stainless steel SUS316/SUS304;

Jacket temperature control,optimized diversion design;

Interior surface polishing ,Ra≤0.6μm; exterior surface polishing or matte treatment;

Wide visual angle long-bar sight glass, PH electrode ,DO electrode, temperature electrode with complete connections;         

The tank cover is equipped with the flame inoculation port and standby feeding port.

Stirring system

Top mechanical stirring system , aseptic mechanical seal system , DC stirring motor or AC motor;

Standard configuration 2-layer flat vane , first-class high-efficiency defoaming vane , bending vane and axial flow vane are optional;

Speed control available , digital setting of rotation speed control.

Structure mode 

Floor type framework , space saving ,  convenient operation.

Ventilating system 

Deep ventilating ,full stainless steel pipe;

Liquid deep ventilating;

Glass rotor flow-meter display , pressure gauge display , manual valve flow adjustment;

Equipped with German Sartorius high-efficiency bacteria removing filter of stainless shell with a precision of 0.01μm;

External compressed air is required , equipped with high quality water removing pressure stabilizer for continuous and stable air supply;

The mass flow controller is optional to automatically control air flow.

Tank pressure control 

The top exhaust port is equipped with the pointer pressure gauge to display the tank pressure. The stainless steel valve adopts manual control.

The optional imported pressure transmitter and automatic control valve realize automatic control of tank pressure

Temperature control

Online inspection , digital setting , free switching between automatic and manual control;

Pt-100 temperature probe;

Electric heating temperature control and external cooling water for automatic temperature control.

PH control

Online inspection , 2-way peristaltic pump automatic incremental feeding of acid or alkali solution for adjustment;

Imported PH electrode realizes high temperature steam disinfection.

Dissolved oxygen(DO)

Online inspection , with a range of 0-100% or 0-200%;

Imported DO electrode realizes high temperature steam disinfection;

Optional , linked control with rotation speed and ventilation.

Feeding control 

Standard configuration 1-way peristaltic pump time proportional incremental feeding , with the volume of incremental feeding being displayed and recorded.

Defoaming mode 

Conducting type foam electrode , automatic alarming in case of abnormal foam situation;

Standard configuration 1-way peristaltic pump automatic/manual incremental feeding of defoaming agent , with the volume of incremental feeding being displayed and recorded.

Control system

Siemens PLC controller true color touch screen with complete functions and stable running .

Sterilizing mode 

SIP , manual control

Equipment features

SIP ,  safety and reliable ;

Without driving leakage risk;

Wide visual angle vertical sight glass with clear observation;

Various reliable inoculation modes (standard configuration flame inoculation port,differential pressure inoculation port and other various optional forma);

Floor type tank with beautiful appearance;

Easy operation , assembly and disassembly;

Products of special specifications can be made to order;

Optional

1.Multi-way feeding

2.Automatic sterilization

3.Weighing of fed materials

4.Tank body weighing

5.Rich oxygen bypass

6.ORP online inspection

7.Air flow automatic inspection and control

8.Tail gas O2,CO2 content online inspection

9.Methanol (alcohol) content online inspection

 

Parameter Category	Parameter Name	Unit Typical	Value/Range Basic
Parameters
Capacity fermentation	Tank capacity	L	10-200
Number	Number of fermentation tanks	A	4-8
Material	Fermentation Tank Material	-	Stainless Steel, Glass, etc
Temperature Control
Temperature range	Fermentation temperature	° C	20-50
Control accuracy Temperature	Control accuracy	±° C	±0.1
Heating methods	Heating methods	-	Electric heating, water bath heating etc
Cooling methods	Cooling methods	-	Water cooling, air cooling, etc
Mixing system
Mixing speed	Mixing speed	rpm	0-1000
Mixing form	Mixing blade type	-	Flat blade, spiral blade, etc
Ventilation system
Ventilation speed	Ventilation rate	L/min	0-10
Ventilation pressure	Ventilation pressure	bar	0-1
PH control system
PH range	PH adjustment range	-	3-10
Control accuracy	PH control accuracy	±	± 0.05
Dissolved oxygen monitoring
Dissolved oxygen range	Dissolved oxygen concentration	% DO	0-100
Measurement accuracy	Dissolved oxygen measurement accuracy	±% DO	± 0.5
Data recording
Data recording interval	Recording time interval	Min	1-60
Storage Capacity	Data Storage Capacity	GB	1-10

The key points of fermentation tank technology mainly focus on the following aspects to ensure efficient and controllable biological fermentation process:

1. Material and structural design: Fermentation tanks are usually made of corrosion-resistant materials such as stainless steel to ensure the cleanliness and sterility of the internal environment. The design of the tank body needs to consider thermal insulation to maintain a constant fermentation temperature. The tank is equipped with baffles, agitators, etc. to promote medium mixing and oxygen transfer.

2. Temperature control: An accurate temperature control system is crucial, usually including heating and cooling devices, to ensure that the temperature remains stable within the range most suitable for microbial growth during the fermentation process.

3. Stirring and ventilation system: The design of the agitator (such as paddle or turbine) should be able to effectively mix the culture medium, prevent sedimentation, and increase dissolved oxygen. At the same time, sterile air or oxygen is introduced into the tank through an air distributor to meet the respiratory needs of microorganisms. Some fermentation processes may also use bubble free ventilation technology to reduce the damage of shear force to cells.

4. PH adjustment: The automatic pH control system adjusts the pH value of the culture medium by adding acid-base solutions to maintain the most suitable conditions for microbial growth.

5. Pressure control: Especially in high-pressure fermentation or situations where external pollution needs to be prevented, the fermentation tank needs to have good sealing and pressure control capabilities.

6. Feeding and discharge: During long-term fermentation, nutrients are automatically added in a timely manner to maintain microbial growth. At the same time, a waste liquid discharge system is designed to remove metabolic products and maintain a stable cultivation environment.

7. Monitoring and automation control: Integrated sensors monitor various parameters (such as temperature, pH, dissolved oxygen, pressure, etc.) and connect with the automation control system to achieve real-time data monitoring and automatic adjustment of fermentation conditions, ensuring process optimization and repeatability.

8. Cleaning and Sterilization: CIP (in place cleaning) and SIP (in place sterilization) capabilities ensure thorough cleaning and disinfection of equipment before and after each use to prevent cross contamination.

9. Safety measures: including pressure safety valves, explosion-proof devices, etc., to ensure safe operation. These technological points together ensure the efficiency, stability, and safety of the fermentation process, and are suitable for various industries such as pharmaceuticals, food, and biofuels.


Customizing a Flowmeter Fermentation Machine mainly involves selecting appropriate components and configurations to ensure that the final product meets specific production or research needs. Here are some key steps and considerations:

Choose the appropriate flow meter: Based on the requirements of the fermentation process, select the appropriate type of flow meter, such as liquid flow meter or gas flow meter. Consider performance parameters such as flow range, accuracy, and corrosion resistance to ensure that the flowmeter can accurately measure fluid flow and adapt to the chemical environment during fermentation.

Determine the specifications and configuration of the fermentation machine: Based on the scale of production or research, determine the capacity, operating temperature range, stirring speed, etc. of the fermentation machine. Consider using a variable area flow meter to regulate air flow and installing a condenser to cool the exhaust gas and maintain stable temperature in the working environment.

Material selection: Choose appropriate materials based on fluid properties, such as stainless steel or special plastics, to ensure the durability and safety of the equipment.

Automation and control system: Consider adding an automation control system to monitor and adjust key parameters of the fermentation process, such as temperature, pH value, etc.

Safety measures: Ensure that the equipment meets safety standards, including installing safety electrodes and temperature sensors, as well as providing necessary safety protection measures.

Customization service: Communicate with us about customization needs, including special size, functional, or performance requirements, to ensure that the final product meets expectations.

After sales service and support: We provide professional after-sales service support, and customers receive necessary maintenance and technical support during the use of the product.

Through the above steps, a Flowmeter Fermentation Machine can be customized to meet specific needs, ensuring accurate flow measurement and effective process control during the fermentation process.

Pre sales services

After-sale service 

 

1. Equipment warranty period: We provide a one-year free warranty service for mechanical equipment. If any non-human caused problems occur during the warranty period, we will provide free repair or replacement services.
2. Maintenance and upkeep services: We provide regular or irregular equipment maintenance and upkeep services to ensure the normal operation of the equipment. We will provide 24-hour online technical support services.
3. Accessory supply: We guarantee to provide original factory accessories in a timely manner in case of equipment damage or replacement of parts.
4. Training services: In order to enable customers to effectively operate and maintain equipment, we will provide equipment operation and maintenance training.
5. Installation and debugging: We will provide equipment installation and debugging services to ensure that the equipment is installed correctly and can operate normally.

 

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FAQ

 

1 ) Q: How can we visit your factory?
A: If you come from abroad, air to shanghai airport, then we can pick you up at airport.

 

2) Q: How do you ensure the quality of your products?
A: Our Company is a state owned enterprise with more than 16 years experience , strict operation policy is performed, advanced processing machines guarangtee the precision of all components, workers with operation license, parts get multiprocessing, transmission& electrical parts are of international famous brand. Series of test and inspection are done in the whole producing state.

 

3) Q: What payment methods your company accept?
A: We accept most of the payment methods , but mainly accept T/T, L/C at sight .

 

4) Q: How long is the warranty time for your products?
A: Our officially promised warranty time is 12 months after commissioning .

 

5) Q: I am new in this field,can you supply us turnkey services?
A: YES.We can supply all the system including Market Analysis/Product Analysis/Location Choice/Processing Flow Design/Equipment Layout Design/Building Design direction/Equipment mode selection/Equipment Manufacturing/Equipment Mounting/Equipment Debugging/Worker Training.

 

6) Q: What ' s the shipment terms and delivery time of your company?
A: Well, the delivery time depend on the quantity of your order. Usually is 20 days . For some customized machine 30 days is necessary.

 

7) Q: Can you supply OEM services?
A: Yes,we have our R&D team,and we have more than 400 workers with workshop area 75000 square meters.

 

8) Q: Do you give any Discount?
A: I will surely try my best to help you get those by the best price and good service at the same time.